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Radiosynthesis of 3‐[ 18 F]fluoropropyl and 4‐[ 18 F]fluorobenzyl triarylphosphonium ions
Author(s) -
Ravert Hayden T.,
Madar Igal,
Dannals Robert F.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.835
Subject(s) - chemistry , radiosynthesis , yield (engineering) , fluoride , radiochemistry , ion , nuclear chemistry , mole , medicinal chemistry , inorganic chemistry , organic chemistry , in vivo , physics , microbiology and biotechnology , biology , thermodynamics
3‐[ 18 F]Fluoropropyl‐, 4‐[ 18 F]fluorobenzyl‐triphenylphosphonium and 4‐[ 18 F]fluorobenzyltris‐4‐dimethylaminophenylphosphonium cations were synthesized in multi‐step reactions from no carrier added (nca) [ 18 F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/µmole (403 mCi/µmole) at end of synthesis (EOS). Copyright © 2004 John Wiley & Sons, Ltd.

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