Radiosynthesis of 3‐[ 18 F]fluoropropyl and 4‐[ 18 F]fluorobenzyl triarylphosphonium ions | Zendy

Ravert Hayden T. | Zendy; Madar Igal | Zendy; Dannals Robert F. | Zendy

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Radiosynthesis of 3‐[ 18 F]fluoropropyl and 4‐[ 18 F]fluorobenzyl triarylphosphonium ions

Author(s) -

Ravert Hayden T.,

Madar Igal,

Dannals Robert F.

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.835

Subject(s) - chemistry , radiosynthesis , yield (engineering) , fluoride , radiochemistry , ion , nuclear chemistry , mole , medicinal chemistry , inorganic chemistry , organic chemistry , in vivo , physics , microbiology and biotechnology , biology , thermodynamics

3‐[ 18 F]Fluoropropyl‐, 4‐[ 18 F]fluorobenzyl‐triphenylphosphonium and 4‐[ 18 F]fluorobenzyltris‐4‐dimethylaminophenylphosphonium cations were synthesized in multi‐step reactions from no carrier added (nca) [ 18 F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/µmole (403 mCi/µmole) at end of synthesis (EOS). Copyright © 2004 John Wiley & Sons, Ltd.

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