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Synthesis of a technetium‐99m labelled L ‐tyrosine derivative with the fac ‐ 99m Tc(I)(CO) 3 ‐core using a simple kit‐procedure
Author(s) -
Schirrmacher Ralf,
Comagic Slobodan,
Schirrmacher Esther,
Rösch Frank
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.831
Subject(s) - chemistry , labelling , derivative (finance) , tyrosine , yield (engineering) , high performance liquid chromatography , biodistribution , technetium 99m , specific activity , extraction (chemistry) , technetium , radiochemistry , chemical synthesis , chromatography , stereochemistry , nuclear chemistry , organic chemistry , nuclear medicine , scintigraphy , enzyme , in vitro , biochemistry , medicine , materials science , financial economics , economics , metallurgy
The synthesis of a novel technetium‐99m labelled derivative of L ‐tyrosine as a potential tumour imaging agent for nuclear medicine diagnosis is reported. The synthesis involved the labelling precursor fac ‐[ 99m Tc(OH 2 )(CO) 3 ] + which was synthesized using the commercially available Isolink ® ‐labelling kit and the tyrosine derivative O‐(N,N‐bis (carboxymethyl)aminoethyl)‐ L ‐tyrosine trifluoroacetate. The labelled compound O ‐( 99m Tc(I)‐tricarbonyl‐ N,N‐bis (carboxymethyl)aminoethyl)‐ L ‐tyrosine was obtained in a radiochemical yield of 70–80% within 60 min with a radiochemical purity greater than 98% without any HPLC purification step. Purification was achieved merely by solid phase extraction. Chemical as well as chiral purity was determined using gradient‐ and chiral HPLC. Copyright © 2004 John Wiley & Sons, Ltd.