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Synthesis of tritiated Cyclosporin A and FK‐506 by metal‐catalyzed hydrogen isotope exchange
Author(s) -
Shevchenko V. P.,
Nagaev I. Yu.,
Myasoedov N. F.,
Andres H.,
Moenius T.,
Susan A.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.827
Subject(s) - chemistry , tritium , tritiated water , hydrogen isotope , catalysis , radiochemistry , hydrogen , specific activity , metal , nuclear chemistry , isotope , organic chemistry , enzyme , physics , quantum mechanics , nuclear physics
Tritium‐labeled Cyclosporin A ( I ) and FK‐506 ( II ) have been prepared using a metal‐catalysed hydrogen isotope exchange procedure and high specific activity tritiated water. Specific activities of the labeled compounds were 0.15 and 0.59 TBq/mmol, respectively. Copyright © 2004 John Wiley & Sons, Ltd.