Synthesis of tritiated Cyclosporin A and FK‐506 by metal‐catalyzed hydrogen isotope exchange | Zendy

Shevchenko V. P. | Zendy; Nagaev I. Yu. | Zendy; Myasoedov N. F. | Zendy; Andres H. | Zendy; Moenius T. | Zendy; Susan A. | Zendy

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Synthesis of tritiated Cyclosporin A and FK‐506 by metal‐catalyzed hydrogen isotope exchange

Author(s) -

Shevchenko V. P.,

Nagaev I. Yu.,

Myasoedov N. F.,

Andres H.,

Moenius T.,

Susan A.

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.827

Subject(s) - chemistry , tritium , tritiated water , hydrogen isotope , catalysis , radiochemistry , hydrogen , specific activity , metal , nuclear chemistry , isotope , organic chemistry , enzyme , physics , quantum mechanics , nuclear physics

Tritium‐labeled Cyclosporin A ( I ) and FK‐506 ( II ) have been prepared using a metal‐catalysed hydrogen isotope exchange procedure and high specific activity tritiated water. Specific activities of the labeled compounds were 0.15 and 0.59 TBq/mmol, respectively. Copyright © 2004 John Wiley & Sons, Ltd.

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