Premium
Use of 1,8‐ bis ‐(dimethylamino)‐naphthalene/H 18 F complex as new radiofluorinating agent
Author(s) -
Pascali Giancarlo,
Kiesewetter Dale O.,
Salvadori Piero A.,
Eckelman William C.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.823
Subject(s) - chemistry , naphthalene , nucleophile , bottleneck , combinatorial chemistry , pet imaging , molecule , imaging agent , organic chemistry , nuclear medicine , catalysis , computer science , in vivo , positron emission tomography , medicine , microbiology and biotechnology , biology , embedded system
Abstract Radiopharmaceuticals containing an 18 F label are of increasing interest due to their utilization in PET imaging. However, the bottleneck in these applications is the limited methods available for introduction of this radionuclide into biologically interesting molecules. In this work, we have evaluated a new radiofluorination method based on the properties of the complex between 1,8‐(dimethylamino)‐naphthalene ( PS ) and [ 18 F]–HF. The results obtained on various model substrates suggest that, in some limited cases, this new procedure can be regarded as a possible alternative to the traditional nucleophilic route using K 222 /K 2 CO 3 in CH 3 CN. Copyright © 2004 John Wiley & Sons, Ltd.