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Synthesis of [ phenyl ‐ 13 C 6 ]lachnanthocarpone and other 13 C‐labelled phenylphenalenones
Author(s) -
Otálvaro Felipe,
Quiñones Winston,
Echeverri Fernando,
Schneider Bernd
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.808
Subject(s) - chemistry , bromobenzene , stereochemistry , organic chemistry , catalysis
[ phenyl ‐ 13 C 6 ]Lachnanthocarpone ([ phenyl ‐ 13 C 6 ]2,6‐dihydroxy‐9‐phenylphenalen‐1‐one), a hypothetical intermediate in the biosynthesis of various natural phenylphenalenones, was prepared in four steps using [U‐ 13 C]bromobenzene to introduce the label. Based on related methodologies further native phenylphenalenones such as [ phenyl ‐ 13 C 6 ]anigorufone, [1‐ 13 C]anigorufone and [4′‐O 13 CH 3 ]4′‐methoxyanigorufone were synthesized in labelled form. Copyright © 2004 John Wiley & Sons, Ltd.