Premium
Microwave‐assisted cyclocondensation of 1,2‐diaminobenzene with [4‐ 18 F]fluorobenzoic acid: microwave synthesis of 2‐([4‐ 18 F]fluorophenyl) benzimidazole
Author(s) -
Getvoldsen Gareth,
Fredriksson Anna,
Elander Nils,
StoneElander Sharon
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.807
Subject(s) - benzimidazole , chemistry , microwave , catalysis , microwave heating , block (permutation group theory) , combinatorial chemistry , nuclear chemistry , organic chemistry , physics , quantum mechanics , geometry , mathematics
Abstract The synthesis of 2‐([4‐ 18 F]fluorophenyl)benzimidazole, which has potential to be used as a building block for many endogenous and pharmaceutical compounds, is reported. A range of solvents and catalysts as well as conventional and microwave heating have been investigated to optimise the reaction conditions. The cyclocondensation of 1,2‐diaminobenzene with radiolabelled [4‐ 18 F]fluorobenzoic acid in neat methanesulphonic and polyphosphoric acids under microwave heating led rapidly to the cyclised phenylbenzimidazole. Copyright © 2004 John Wiley & Sons, Ltd.