Microwave‐assisted cyclocondensation of 1,2‐diaminobenzene with [4‐ 18 F]fluorobenzoic acid: microwave synthesis of 2‐([4‐ 18 F]fluorophenyl) benzimidazole | Zendy

Getvoldsen Gareth | Zendy; Fredriksson Anna | Zendy; Elander Nils | Zendy; StoneElander Sharon | Zendy

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Microwave‐assisted cyclocondensation of 1,2‐diaminobenzene with [4‐ 18 F]fluorobenzoic acid: microwave synthesis of 2‐([4‐ 18 F]fluorophenyl) benzimidazole

Author(s) -

Getvoldsen Gareth,

Fredriksson Anna,

Elander Nils,

StoneElander Sharon

Publication year - 2004

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.807

Subject(s) - benzimidazole , chemistry , microwave , catalysis , microwave heating , block (permutation group theory) , combinatorial chemistry , nuclear chemistry , organic chemistry , physics , quantum mechanics , geometry , mathematics

The synthesis of 2‐([4‐ 18 F]fluorophenyl)benzimidazole, which has potential to be used as a building block for many endogenous and pharmaceutical compounds, is reported. A range of solvents and catalysts as well as conventional and microwave heating have been investigated to optimise the reaction conditions. The cyclocondensation of 1,2‐diaminobenzene with radiolabelled [4‐ 18 F]fluorobenzoic acid in neat methanesulphonic and polyphosphoric acids under microwave heating led rapidly to the cyclised phenylbenzimidazole. Copyright © 2004 John Wiley & Sons, Ltd.

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