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The synthesis of tritium labelled neurokinin‐1 receptor ligands
Author(s) -
Hamill Terence G.,
Burns H. Donald
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.802
Subject(s) - chemistry , tritium , in vivo , iodide , radiochemistry , in vitro , chemical synthesis , receptor , tachykinin receptor 1 , stereochemistry , biochemistry , organic chemistry , substance p , neuropeptide , physics , microbiology and biotechnology , nuclear physics , biology
Radiolabelled neurokinin‐1 (NK 1 ) receptor antagonists 1b and 2b were required for in vitro/in vivo characterization to support the development of 1a and 2a as fluorine‐18 labelled PET ligands. These tritium labelled compounds were synthesized from aryl iodide precursors giving the final tritiated tracers with specific activities of 28 ( 1b ) and 14 ( 2b ) Ci/mmol. Copyright © 2004 John Wiley & Sons, Ltd.