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Synthesis of tritium labelled 3( R )‐HETE and 3( R ),18( R / S )‐DiHETE through a common synthetic route
Author(s) -
Groza Natalya V.,
Ivanov Igor V.,
Romanov Stepan G.,
Shevchenko Valery P.,
Myasoedov Nikolai F.,
Nigam Santosh,
Myagkova Galina I.
Publication year - 2004
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.791
Subject(s) - tritium , chemistry , stereoselectivity , radiochemistry , stereochemistry , chemical synthesis , organic chemistry , catalysis , nuclear physics , in vitro , biochemistry , physics
Abstract An efficient procedure for the synthesis of 3‐hydroxyoxylipins labelled with tritium on all double bond positions is reported. The synthetic scheme involves a joint route for the formation of tetraacetylenic precursors followed by stereoselective reduction of the triple bonds either with hydrogen or tritium. The final tritiated products were obtained with specific activities ranging from 1.65 to 1.80 Ci/mmol. Copyright © 2003 John Wiley & Sons, Ltd.