Radiosynthesis of [ N ‐methyl‐ 11 C]methylene blue | Zendy

Schweiger Lutz | Zendy; Craib Stuart | Zendy; Welch Andrew | Zendy; Sharp Peter | Zendy

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Radiosynthesis of [ N ‐methyl‐ 11 C]methylene blue

Author(s) -

Schweiger Lutz,

Craib Stuart,

Welch Andrew,

Sharp Peter

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.784

Subject(s) - chemistry , radiosynthesis , methylene blue , trifluoromethanesulfonate , methylene , yield (engineering) , methylation , radiochemistry , nuclear chemistry , medicinal chemistry , organic chemistry , catalysis , in vivo , biochemistry , materials science , microbiology and biotechnology , photocatalysis , gene , metallurgy , biology

In this paper we present the radiochemical synthesis of the novel compound [ N ‐methyl‐ 11 C]methylene blue. The synthesis of [ N ‐methyl‐ 11 C]methylene blue was accomplished by means of 11 C‐methylation of commercially available Azure B using [ 11 C]methyl trifluoromethanesulfonate ([ 11 C]methyl triflate). Following purification [ N ‐methyl‐ 11 C]methylene blue was obtained with a radiochemical purity greater than 97% in a 4–6% decay corrected radiochemical yield. The synthesis was completed in an average of 35 min following the end of bombardment. Copyright © 2003 John Wiley & Sons, Ltd.

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