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Radiosynthesis of [ N ‐methyl‐ 11 C]methylene blue
Author(s) -
Schweiger Lutz,
Craib Stuart,
Welch Andrew,
Sharp Peter
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.784
Subject(s) - chemistry , radiosynthesis , methylene blue , trifluoromethanesulfonate , methylene , yield (engineering) , methylation , radiochemistry , nuclear chemistry , medicinal chemistry , organic chemistry , catalysis , in vivo , biochemistry , materials science , microbiology and biotechnology , photocatalysis , gene , metallurgy , biology
In this paper we present the radiochemical synthesis of the novel compound [ N ‐methyl‐ 11 C]methylene blue. The synthesis of [ N ‐methyl‐ 11 C]methylene blue was accomplished by means of 11 C‐methylation of commercially available Azure B using [ 11 C]methyl trifluoromethanesulfonate ([ 11 C]methyl triflate). Following purification [ N ‐methyl‐ 11 C]methylene blue was obtained with a radiochemical purity greater than 97% in a 4–6% decay corrected radiochemical yield. The synthesis was completed in an average of 35 min following the end of bombardment. Copyright © 2003 John Wiley & Sons, Ltd.