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Synthesis of [ 18 F]Fluoroclofilium as a potential cardiac imaging agent for PET studies
Author(s) -
Yu K. H.,
Kim Y. S.,
Kim S. W.,
Park J. H.,
Yang S. D.,
Herdering W.,
Knoechel A.
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.747
Subject(s) - chemistry , pet imaging , acetonitrile , ammonium , salt (chemistry) , nuclear chemistry , radiochemistry , medicinal chemistry , nuclear medicine , organic chemistry , positron emission tomography , medicine
N ‐4‐(4‐chlorophenyl)butyl‐ N , N ‐diethyl‐7‐[ 18 F]fluoroheptylammonium ([ 18 F]‐fluoroclofilium) has been prepared as a potential cardiac imaging agent. For the synthesis of this radiolabelled ammonium salt, its tosyloxylated analogue was prepared as a precursor, and the non‐radioactive fluorine analogue was synthesized as a reference compound. Radiofluorination was achieved by the treatment of N ‐4‐(4‐chlorophenyl)butyl‐ N , N ‐diethyl‐7‐( p ‐toluenesulfonyloxy)heptylammonium p ‐toluenesulfonate with 18 F − in the presence of Kryptofix‐2.2.2 in acetonitrile. Copyright © 2003 John Wiley & Sons, Ltd.
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