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Expedient synthesis of [ 18 F]‐labeled α‐trifluoromethyl ketones
Author(s) -
Surya Prakash G. K.,
Alauddin Mian M.,
Hu Jinbo,
Conti Peter S.,
Olah George A.
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.741
Subject(s) - chemistry , trifluoromethyl , specific activity , chemical synthesis , aryl , radiochemistry , column chromatography , pet imaging , chromatography , organic chemistry , in vitro , alkyl , nuclear medicine , positron emission tomography , medicine , biochemistry , enzyme
Several [ 18 F]‐labeled α‐trifluoromethyl ketones have been synthesized. Reactions of 2,2‐difluoro‐1‐aryl‐1‐trimethylsiloxyethenes ( 1a–d ) with [ 18 F]‐F 2 at low temperature produced [ 18 F]‐labeled α‐trifluoromethyl ketones ( 2a–d ). Radio‐labeled products were isolated by purification with column chromatography in 22–28% yields, decay corrected (d.c.) in three runs per compound. Radiochemical purity was >99% with specific activities 15–20 GBq/mmol at the end of synthesis (EOS). The synthesis time was 35–40 min from the end of bombardment (EOB). This one‐step simple method is highly useful for the radiochemical synthesis of potential biologically active [ 18 F]‐labeled α‐trifluoromethyl ketones for PET imaging. Copyright © 2003 John Wiley & Sons, Ltd.