Regioselective F‐18 radiolabeling of AM694, a CB 1  cannabinoid receptor ligand | Zendy

Willis Peter G. | Zendy; KatochRouse Reeti | Zendy; Horti Andrew G. | Zendy

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Regioselective F‐18 radiolabeling of AM694, a CB 1 cannabinoid receptor ligand

Author(s) -

Willis Peter G.,

KatochRouse Reeti,

Horti Andrew G.

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.720

Subject(s) - chemistry , regioselectivity , cannabinoid receptor , cannabinoid , yield (engineering) , ligand (biochemistry) , radiochemistry , medicinal chemistry , stereochemistry , receptor , nuclear chemistry , organic chemistry , biochemistry , antagonist , materials science , metallurgy , catalysis

[ 18 F]AM694, [1‐(5‐[ 18 F]fluoropentyl)‐1H‐indol‐3‐yl]‐(2‐iodophenyl)methanone, 1b , a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1 ), has been synthesized by no‐carrier‐added regioselective radiofluorination of the corresponding tosylate. [ 18 F]AM694 was obtained in 20% radiochemical yield (non‐decay‐corrected) with a specific activity of 14 500 mCi/µmol, a radiochemical purity of > 99%, and a chemical purity of 95.5%. Copyright © 2003 John Wiley & Sons, Ltd.

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