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Regioselective F‐18 radiolabeling of AM694, a CB 1 cannabinoid receptor ligand
Author(s) -
Willis Peter G.,
KatochRouse Reeti,
Horti Andrew G.
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.720
Subject(s) - chemistry , regioselectivity , cannabinoid receptor , cannabinoid , yield (engineering) , ligand (biochemistry) , radiochemistry , medicinal chemistry , stereochemistry , receptor , nuclear chemistry , organic chemistry , biochemistry , antagonist , materials science , metallurgy , catalysis
[ 18 F]AM694, [1‐(5‐[ 18 F]fluoropentyl)‐1H‐indol‐3‐yl]‐(2‐iodophenyl)methanone, 1b , a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1 ), has been synthesized by no‐carrier‐added regioselective radiofluorination of the corresponding tosylate. [ 18 F]AM694 was obtained in 20% radiochemical yield (non‐decay‐corrected) with a specific activity of 14 500 mCi/µmol, a radiochemical purity of > 99%, and a chemical purity of 95.5%. Copyright © 2003 John Wiley & Sons, Ltd.