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A novel probe for imaging amyloid‐β: Synthesis of F‐18 labelled BF‐108, an Acridine Orange analog
Author(s) -
Shimadzu Hiroshi,
Suemoto Takahiro,
Suzuki Masako,
Shiomitsu Tsuyoshi,
Okamura Nobuyuki,
Kudo Yukitsuka,
Sawada Tohru
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.716
Subject(s) - chemistry , high performance liquid chromatography , pet imaging , acetonitrile , chemical synthesis , specific activity , radiochemistry , nuclear chemistry , chromatography , positron emission tomography , organic chemistry , nuclear medicine , biochemistry , medicine , in vitro , enzyme
The synthesis of 3‐(2‐[ 18 F]fluoroethyl)ethylamino‐6‐diethylaminoacridine ([ 18 F]BF‐108), a potential positron‐labelled probe for imaging amyloid‐β is described. The precursor tosylate derivative was fluorinated with [ 18 F]KF/ Kryptofix 222 in acetonitrile, and the crude product was purified by semi‐preparative HPLC to give the radiolabelled BF‐108. The radiochemical purity was >95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB). Copyright © 2003 John Wiley & Sons, Ltd.
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