125 I‐Labeled 2‐ O ‐ and 3‐ O ‐ m‐ iodobenzyl, and 6‐ O ‐ m‐ iodophenyl derivatives of L‐ascorbic acid: synthesis and preliminary tissue distribution | Zendy

Yamamoto Fumihiko | Zendy; Kuwano Eri | Zendy; Kaneshiro Tetsuo | Zendy; Sasaki Shigeki | Zendy; Maeda Minoru | Zendy

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125 I‐Labeled 2‐ O ‐ and 3‐ O ‐ m‐ iodobenzyl, and 6‐ O ‐ m‐ iodophenyl derivatives of L‐ascorbic acid: synthesis and preliminary tissue distribution

Author(s) -

Yamamoto Fumihiko,

Kuwano Eri,

Kaneshiro Tetsuo,

Sasaki Shigeki,

Maeda Minoru

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.714

Subject(s) - ascorbic acid , chemistry , biodistribution , in vivo , high performance liquid chromatography , stereochemistry , radiochemistry , chromatography , in vitro , biochemistry , food science , microbiology and biotechnology , biology

Three 125 I‐labeled 2 ‐O‐ and 3 ‐O‐m‐ iodobenzyl, and 6 ‐O‐m‐ iodophenyl derivatives of L ‐ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12–60% after HPLC purification. Biodistribution studies in tumor‐bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14 C‐labeled ascorbic acid and 6‐deoxy‐6‐[ 18 F]fluoro‐ L ‐ascorbic acid. None of these seems to be suitable radioiodinated analogs of L ‐ascorbic acid for imaging study of its in vivo biochemistry. Copyright © 2003 John Wiley & Sons, Ltd.

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