Automated commercial synthesis system for preparation of O‐(2‐[ 18 F]fluoroethyl)‐L‐tyrosine by direct nucleophilic displacement on a resin column | Zendy

Tang Ganghua | Zendy; Tang Xiaolan | Zendy; Wang Mingfang | Zendy; Luo Lei | Zendy; Gan Manquan | Zendy; Huang Zuhan | Zendy

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Automated commercial synthesis system for preparation of O‐(2‐[ 18 F]fluoroethyl)‐L‐tyrosine by direct nucleophilic displacement on a resin column

Author(s) -

Tang Ganghua,

Tang Xiaolan,

Wang Mingfang,

Luo Lei,

Gan Manquan,

Huang Zuhan

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.706

Subject(s) - chemistry , nucleophile , yield (engineering) , pyridinium , fluoride , radiochemistry , polystyrene , tyrosine , nuclear chemistry , medicinal chemistry , organic chemistry , catalysis , inorganic chemistry , biochemistry , materials science , polymer , metallurgy

A slightly modified automated commercial synthesis system for preparation of O ‐(2‐[ 18 F]fluoroethyl)‐l‐tyrosine (FET), an amino acid tracer for tumor imaging with positron emission tomography, is described. Direct nucleophilic fluorination of [ 18 F]fluoride with 1,2‐di(4‐methylphenylsulfonyloxy)ethane on a quaternary 4‐(4‐methylpiperidinyl)‐pyridinium functionalized polystyrene anion exchange resin gave 1‐[ 18 F]‐2‐(4‐methylphenylsulfonyloxy)ethane, then [ 18 F]fluoroalkylation of l‐tyrosine yielded FET. The overall radiochemical yield with no decay correction was about 8–10%, the whole synthesis time was about 52 min, and the radiochemical purity was above 95%. Copyright © 2003 John Wiley & Sons, Ltd.

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