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Synthesis of tritium labelled L783483 ‐ a PPAR δ ligand
Author(s) -
GrueSørensen Gunnar,
Høj Nicolaj
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.687
Subject(s) - chemistry , tritium , ligand (biochemistry) , trifluoromethyl , phenylacetic acid , specific activity , tritium illumination , bromine , radiochemistry , receptor , peroxisome proliferator activated receptor , nuclear chemistry , medicinal chemistry , organic chemistry , biochemistry , enzyme , nuclear physics , physics , alkyl
The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [ 3 H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.