Synthesis of tritium labelled L783483 ‐ a PPAR δ  ligand | Zendy

GrueSørensen Gunnar | Zendy; Høj Nicolaj | Zendy

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Synthesis of tritium labelled L783483 ‐ a PPAR δ ligand

Author(s) -

GrueSørensen Gunnar,

Høj Nicolaj

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.687

Subject(s) - chemistry , tritium , ligand (biochemistry) , trifluoromethyl , phenylacetic acid , specific activity , tritium illumination , bromine , radiochemistry , receptor , peroxisome proliferator activated receptor , nuclear chemistry , medicinal chemistry , organic chemistry , biochemistry , enzyme , nuclear physics , physics , alkyl

The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [ 3 H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.

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