Synthesis of [ 14 C]‐ l ‐tryptophan and [ 14 C]‐5′‐hydroxy‐ l ‐tryptophan labeled in the carboxyl group | Zendy

Boroda E. | Zendy; Kański R. | Zendy; Kańska M. | Zendy

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Synthesis of [ 14 C]‐ l ‐tryptophan and [ 14 C]‐5′‐hydroxy‐ l ‐tryptophan labeled in the carboxyl group

Author(s) -

Boroda E.,

Kański R.,

Kańska M.

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.685

Subject(s) - chemistry , tryptophanase , tryptophan , indole test , transaminase , enzyme , stereochemistry , oxidase test , biochemistry , amino acid

The synthesis of selectively 14 C‐labeled l ‐tryptophan and its derivative 5‐hydroxy‐ l ‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐ 14 C[‐ dl ‐alanine, indole or 5‐hydroxyindole has been converted to [1‐ 14 C]‐ l ‐tryptophan or 5′‐hydroxy‐[1‐ 14 C]‐ l ‐tryptophan, respectively, in a one‐pot multienzymatic reaction using four enzymes: d ‐amino acid oxidase, catalase, glutamic‐pyruvic transaminase and tryptophanase. Copyright © 2003 John Wiley & Sons, Ltd.

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