Synthesis of  14 C‐labelled myosmine, [2′‐ 14 C] ‐3‐(1‐pyrrolin‐2‐yl)pyridine | Zendy

Tyroller Stefan | Zendy; Zwickenpflug Wolfgang | Zendy; Richter Elmar | Zendy

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Synthesis of 14 C‐labelled myosmine, [2′‐ 14 C] ‐3‐(1‐pyrrolin‐2‐yl)pyridine

Author(s) -

Tyroller Stefan,

Zwickenpflug Wolfgang,

Richter Elmar

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.678

Subject(s) - chemistry , pyridine , yield (engineering) , sodium hydride , silica gel , chromatography , column chromatography , chemical synthesis , high performance liquid chromatography , organic chemistry , biochemistry , in vitro , materials science , metallurgy

14 C‐Labelled myosmine ([2′‐ 14 C]‐3‐(1‐pyrrolin‐2‐yl)pyridine) was synthesized for autoradiography studies starting from [carboxyl‐ 14 C]‐nicotinic acid by initial esterification of the latter in the presence of 1,1,1‐triethoxyethane. Without any purification the ethyl nicotinate formed was directly reacted with N ‐vinyl‐2‐pyrrolidinone in the presence of sodium hydride, yielding 14 C‐labelled myosmine. The product was purified by silica gel column chromatography. The radiochemical yield was 15% and the specific activity 55.2 mCi/mmol. Copyright © 2003 John Wiley & Sons, Ltd.

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