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A practical laboratory route to the synthesis of trideuteriomethyl‐[ 13 C] iodide
Author(s) -
Coumbarides Gregory S.,
Eames Jason,
Weerasooriya Neluka
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.666
Subject(s) - chemistry , iodide , yield (engineering) , methanol , radiochemistry , chemical synthesis , methyl iodide , organic chemistry , biochemistry , in vitro , materials science , metallurgy
A practical synthetic laboratory route for the synthesis of trideuteriomethyl‐[ 13 C] iodide ( 13 CD 3 I) (from tetradeuterio‐[ 13 C]‐methanol and hydriodic acid) is described. We comment on the experimental protocol, and the use of water as an ‘additive’ to improve the synthetic yield. Copyright © 2003 John Wiley & Sons, Ltd.
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