Radiochemical stability of  14 C‐compounds on storage: benefits of thioethers | Zendy

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Radiochemical stability of 14 C‐compounds on storage: benefits of thioethers

Author(s) -

Fredenhagen Andreas

Publication year - 2003

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.660

Subject(s) - chemistry , dichloromethane , decomposition , solvent , organic chemistry , chromatography

Storage of radiochemicals is a significant practical problem. Storage as a solution in various solvents was compared to the storage as a neat oil or solid over an extended period of time. Dichloromethane, a solvent previously not recommended for storage, was found to be a good choice in certain solvent mixtures. Addition of methylsulfide or 2‐methyl‐2‐butene was shown to reduce the radiochemical decomposition by a factor of 1.7–3.2 in ethanol‐free solvents. General points to consider for storage of radiochemicals are discussed. Radiochemical purity was determined by HPLC. Copyright © 2002 John Wiley & Sons, Ltd.

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