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Radiochemical stability of 14 C‐compounds on storage: benefits of thioethers
Author(s) -
Fredenhagen Andreas
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.660
Subject(s) - chemistry , dichloromethane , decomposition , solvent , organic chemistry , chromatography
Storage of radiochemicals is a significant practical problem. Storage as a solution in various solvents was compared to the storage as a neat oil or solid over an extended period of time. Dichloromethane, a solvent previously not recommended for storage, was found to be a good choice in certain solvent mixtures. Addition of methylsulfide or 2‐methyl‐2‐butene was shown to reduce the radiochemical decomposition by a factor of 1.7–3.2 in ethanol‐free solvents. General points to consider for storage of radiochemicals are discussed. Radiochemical purity was determined by HPLC. Copyright © 2002 John Wiley & Sons, Ltd.