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Synthesis of deuterated 4,4′‐diaminodiphenylsulfone (Dapsone) and related analogs
Author(s) -
Gannett Peter M.,
Johnson Edward M.,
Grimes Michael A.,
Myers Alan L.,
Deavers Robert E.,
Tracy Timothy S.
Publication year - 2003
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.649
Subject(s) - sulfone , dapsone , chemistry , aniline , phenol , organic chemistry , stereochemistry , dermatology , medicine
A general scheme for the synthesis of 4,4′‐diaminodiphenylsulfone‐d 5 (Dapsone) from aniline‐d 5 is described. The method may have general application and the preparation of the related analogs, 4,4′‐dimethylaminodiphenyl sulfone from aniline‐d 5 and 4,4′‐dimethoxydiphenyl sulfone from phenol‐d 5 , is also described. Copyright © 2002 John Wiley & Sons, Ltd.