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Synthesis of [ 2 H 3 ]‐dextromethorphan and its major urinary metabolites [ 2 H 3 ]‐dextrorphan and [ 2 H 3 ]‐dextrorphan‐ β ‐glucuronide
Author(s) -
Heinkele Georg,
Schänzle Gerhard,
Mürdter Thomas E.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.640
Subject(s) - dextrorphan , dextromethorphan , chemistry , yield (engineering) , levorphanol , stereochemistry , pharmacology , biochemistry , medicine , (+) naloxone , materials science , receptor , opioid , metallurgy
Starting from dextromethorphan, [ 2 H 3 ]‐dextrorphan‐ β ‐glucuronide was synthesized in four steps with [ 2 H 3 ]‐dextromethorphan and [ 2 H 3 ]‐dextrorphan as intermediates with an overall yield of 11%. Copyright © 2002 John Wiley & Sons, Ltd.