Premium
Isotopic labeling of 2‐desoxoparaherquamide A (PNU‐141962) with deuterium
Author(s) -
Lee Byung H.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.624
Subject(s) - chemistry , deuterium , anticipation (artificial intelligence) , radiochemistry , isotopic labeling , isotope , combinatorial chemistry , organic chemistry , nuclear physics , physics , artificial intelligence , computer science
Modifications of marcfortine A and paraherquamide A led to the discovery of 2‐desoxoparaherquamide A (PNU‐141962, 3 ) which is as active as paraherquamide A and has an improved safety profile. In order to do preclinical studies, we wished to synthesize isotope‐labeled PNU‐141962. This account will describe the synthesis of [CD 3 ]‐2‐desoxoparaherquamide A ( 4 ). The deuterium product was prepared in anticipation of using a similar synthesis for the preparation of the corresponding 14 C‐ and 3 H‐labeled products. Copyright © 2002 John Wiley & Sons, Ltd.