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Radiosynthesis of [ 123 I] N ‐(3‐iodoprop‐(2 E )‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter
Author(s) -
Yu Meixiang,
Airaksinen Anu J.,
Gee Antony D.,
Lötjönen Simo,
Kuikka Jyrki T.,
Vepsäläinen Jouko J.,
Hiltunen Jukka,
Bergström Kim A.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.619
Subject(s) - chemistry , tropane , radiosynthesis , dopamine transporter , iodine 123 , radiochemistry , derivative (finance) , yield (engineering) , stereochemistry , chemical synthesis , bicyclic molecule , transporter , biochemistry , in vitro , nuclear medicine , positron emission tomography , medicine , materials science , gene , metallurgy , financial economics , economics
Abstract The radiosynthesis of a novel tropane derivative [ 123 I]KUC‐25019, [[ 123 I]; N ‐(3‐iodoprop‐(2 E )‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123 I‐labeling synthesis. The no‐carrier‐added 123 I‐labeling has about 20% yield, the specific activity of [ 123 I]KUC‐25019 is > 107 GBq/µmol and the radiochemical purity of [ 123 I] KUC‐25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.