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The first synthesis of all possible isotopically labelled [D, 13 C] methyl group combinations of 2,2‐dimethyl tetralone
Author(s) -
Coumbarides Gregory S.,
Eames Jason,
Weerasooriya Neluka
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.613
Subject(s) - chemistry , tetralones , tetralone , deprotonation , methylation , carbon 13 , stereochemistry , organic chemistry , ion , biochemistry , gene , physics , quantum mechanics
A series of multi‐labelled [D, 13 C] 2,2‐dimethyl tetralones were efficiently synthesized using a simple and diverse deprotonation–methylation strategy. All possible ten isotopic combinations were synthesized. The levels of [D, 13 C] isotopic incorporation were quantitative and the synthetic yields were high. Copyright © 2002 John Wiley & Sons, Ltd.