The first synthesis of all possible isotopically labelled [D,  13 C] methyl group combinations of 2,2‐dimethyl tetralone | Zendy

Coumbarides Gregory S. | Zendy; Eames Jason | Zendy; Weerasooriya Neluka | Zendy

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The first synthesis of all possible isotopically labelled [D, 13 C] methyl group combinations of 2,2‐dimethyl tetralone

Author(s) -

Coumbarides Gregory S.,

Eames Jason,

Weerasooriya Neluka

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.613

Subject(s) - chemistry , tetralones , tetralone , deprotonation , methylation , carbon 13 , stereochemistry , organic chemistry , ion , biochemistry , gene , physics , quantum mechanics

A series of multi‐labelled [D, 13 C] 2,2‐dimethyl tetralones were efficiently synthesized using a simple and diverse deprotonation–methylation strategy. All possible ten isotopic combinations were synthesized. The levels of [D, 13 C] isotopic incorporation were quantitative and the synthetic yields were high. Copyright © 2002 John Wiley & Sons, Ltd.

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