Synthesis of covalent [ 14 C]‐labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL‐1 | Zendy

Eggler J. F. | Zendy; Gabel C. A. | Zendy; Zandi K. | Zendy; Weaver J. D. | Zendy; McKechney H. | Zendy; Dombroski M. A. | Zendy; Peurano H. | Zendy; Hawryluk N. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of covalent [ 14 C]‐labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL‐1

Author(s) -

Eggler J. F.,

Gabel C. A.,

Zandi K.,

Weaver J. D.,

McKechney H.,

Dombroski M. A.,

Peurano H.,

Hawryluk N.

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.602

Subject(s) - chemistry , phosgene , covalent bond , sulfonamide , epoxide , combinatorial chemistry , chemical synthesis , stereochemistry , biochemistry , organic chemistry , in vitro , catalysis

CP‐452,759 and CP‐470,947, two covalent [ 14 C]‐labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL‐1 from human monocytes, have been synthesized. The radiosyntheses utilize [ 14 C]‐labeled phosgene to prepare labeled isocyanates which are coupled with an epoxide sulfonamide to give the [ 14 C]‐DASUs. These tools should allow future studies aimed at purifying and identifying the DASU binding protein involved in the inhibition of the processing and release of IL‐1 from human monocytes. Copyright © 2002 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research