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Synthesis of 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine with relatively high‐specific activity
Author(s) -
Vähätalo Jyrki K.,
Eskola Olli,
Bergman Jörgen,
Forsback Sarita,
Lehikoinen Pertti,
Jääskeläinen Juha,
Solin Olof
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.600
Subject(s) - chemistry , boron , specific activity , high performance liquid chromatography , radiochemistry , electrophile , chromatography , organic chemistry , enzyme , catalysis
An alternative procedure to produce 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine ([ 18 F]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high‐specific activity electrophilic radiofluorine is produced using a post‐target conversion of [ 18 F]F – to [ 18 F]F 2 . Liquid chromatography with mass spectrometric detection is used to estimate the specific radioactivity of [ 18 F]FBPA and to verify the quality control for chemical identity of the target compound. [ 18 F]FBPA produced according to this method fulfilled the pharmaceutical quality requirements for an injection in patients. Copyright © 2002 John Wiley & Sons, Ltd.