Synthesis of 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine with relatively high‐specific activity | Zendy

Vähätalo Jyrki K. | Zendy; Eskola Olli | Zendy; Bergman Jörgen | Zendy; Forsback Sarita | Zendy; Lehikoinen Pertti | Zendy; Jääskeläinen Juha | Zendy; Solin Olof | Zendy

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Synthesis of 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine with relatively high‐specific activity

Author(s) -

Vähätalo Jyrki K.,

Eskola Olli,

Bergman Jörgen,

Forsback Sarita,

Lehikoinen Pertti,

Jääskeläinen Juha,

Solin Olof

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.600

Subject(s) - chemistry , boron , specific activity , high performance liquid chromatography , radiochemistry , electrophile , chromatography , organic chemistry , enzyme , catalysis

An alternative procedure to produce 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine ([ 18 F]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high‐specific activity electrophilic radiofluorine is produced using a post‐target conversion of [ 18 F]F – to [ 18 F]F 2 . Liquid chromatography with mass spectrometric detection is used to estimate the specific radioactivity of [ 18 F]FBPA and to verify the quality control for chemical identity of the target compound. [ 18 F]FBPA produced according to this method fulfilled the pharmaceutical quality requirements for an injection in patients. Copyright © 2002 John Wiley & Sons, Ltd.

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