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Microwave applications in radiolabelling with short‐lived positron‐emitting radionuclides
Author(s) -
StoneElander Sharon,
Elander Nils
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.593
Subject(s) - chemistry , microwave , positron , decomposition , radionuclide , radiochemistry , flexibility (engineering) , positron emission tomography , chemical reaction , combinatorial chemistry , organic chemistry , nuclear physics , nuclear medicine , electron , medicine , physics , statistics , mathematics , quantum mechanics
The use of microwave dielectric heating to reduce reaction times in organic transformations is rapidly increasing worldwide. Besides the time gains from simply performing reactions faster, other advantages have been noted, e.g. cleaner reaction mixtures due to decreased sample decomposition and altered product distributions as well as improved chemical flexibility due to the ability to accelerate typically sluggish reactions of less activated substrates. Microwave applications in radiolabelling tracers for positron emission tomography, paralleling and sometimes preceding developments in other areas of microwave‐enhanced chemistry, are reviewed here. Copyright © 2002 John Wiley & Sons, Ltd.