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Synthesis of tritium labeled isotopomers of L ‐tyrosine
Author(s) -
Augustyniak W.,
Suchecki P.,
Jemielity J.,
Kański R.,
Kańska M.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.582
Subject(s) - isotopomers , chemistry , tritium , phenylalanine , tyrosine , enzyme , chemical synthesis , stereochemistry , biochemistry , organic chemistry , amino acid , molecule , in vitro , physics , nuclear physics
The synthesis of four selectively labeled isotopomers of L ‐tyrosine, ( L ‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L ‐phenylalanine ( L ‐Phe) – [2‐ 3 H]‐, [2′,6′‐ 3 H 2 ]‐, [3R‐ 3 H]‐ and [3S‐ 3 H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L ‐Phe have been converted into [2 ‐ 3 H]‐, [2′,6′‐ 3 H 2 ]‐, [3R‐ 3 H]‐, and [3S‐ 3 H]‐ L ‐Tyr by using the enzyme L ‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.