Premium
Radiosynthesis of [ 11 C]paclitaxel
Author(s) -
Ravert Hayden T.,
Klecker Raymond W.,
Collins Jerry M.,
Mathews William B.,
Pomper Martin G.,
Wahl Richard L.,
Dannals Robert F.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.571
Subject(s) - chemistry , radiosynthesis , paclitaxel , yield (engineering) , chloride , radiochemistry , amine gas treating , nuclear chemistry , benzoyl chloride , specific activity , organic chemistry , nuclear medicine , chemotherapy , surgery , medicine , materials science , metallurgy , positron emission tomography , enzyme
[ 11 C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [ α ‐ 11 C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity. Copyright © 2002 John Wiley & Sons, Ltd.