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A convenient synthesis of [ 11 C]paraquat and other [ N ‐methyl‐ 11 C]bisquaternary ammonium compounds
Author(s) -
Jewett Douglas M.,
Kilbourn Michael R.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.564
Subject(s) - chemistry , trifluoromethanesulfonate , ammonium , salt (chemistry) , chelation , paraquat , ion exchange , medicinal chemistry , organic chemistry , ion , catalysis
[ 11 C]Paraquat was synthesized by the reaction of [ 11 C]methyl triflate with the mono‐triflate salt of 1‐methyl‐[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method was applied to the synthesis of a variety of [ N ‐methyl‐ 11 C]bisquaternary ammonium compounds. This is the first reported use of a chelating cation exchange resin for the selective purification of organic dications. Copyright © 2002 John Wiley & Sons, Ltd.