A convenient synthesis of [ 11 C]paraquat and other [ N ‐methyl‐ 11 C]bisquaternary ammonium compounds | Zendy

Jewett Douglas M. | Zendy; Kilbourn Michael R. | Zendy

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A convenient synthesis of [ 11 C]paraquat and other [ N ‐methyl‐ 11 C]bisquaternary ammonium compounds

Author(s) -

Jewett Douglas M.,

Kilbourn Michael R.

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.564

Subject(s) - chemistry , trifluoromethanesulfonate , ammonium , salt (chemistry) , chelation , paraquat , ion exchange , medicinal chemistry , organic chemistry , ion , catalysis

[ 11 C]Paraquat was synthesized by the reaction of [ 11 C]methyl triflate with the mono‐triflate salt of 1‐methyl‐[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method was applied to the synthesis of a variety of [ N ‐methyl‐ 11 C]bisquaternary ammonium compounds. This is the first reported use of a chelating cation exchange resin for the selective purification of organic dications. Copyright © 2002 John Wiley & Sons, Ltd.

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