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Synthesis of two novel oxocyclam‐binding technetium complexes containing an analogue of cocaine
Author(s) -
Turpin F.,
Masri F.,
Riché F.,
Berthommier E.,
Emond P.,
Vidal M.,
Auzeloux P.,
Loc'h C.,
Neuquelman N.,
Mauclaire L.
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.560
Subject(s) - tropane , chemistry , dopamine transporter , moiety , dopamine , dopamine plasma membrane transport proteins , transporter , stereochemistry , technetium , technetium 99m , combinatorial chemistry , biochemistry , scintigraphy , neuroscience , nuclear medicine , medicine , biology , nuclear chemistry , gene
In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium‐99 m ( 99m Tc) has been investigated. A multi‐step synthesis afforded two target ligands with a tropane skeleton and a macrocyclic complexing moiety. The choice and the position of substituents are in adequation with dopamine transporter structure. The radiolabelling of these ligands with 99m Tc has been studied and the results make them good candidates for SPECT imaging. Copyright © 2002 John Wiley & Sons, Ltd.