Synthesis of  N ‐(2‐chloro‐3,4‐dimethoxybenzylideneamino)guanidinium acetate [ α ‐ 14 C] | Zendy

Almeida Maria | Zendy; Boman Arne | Zendy; Lundstedt Torbjörn | Zendy

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Synthesis of N ‐(2‐chloro‐3,4‐dimethoxybenzylideneamino)guanidinium acetate [ α ‐ 14 C]

Author(s) -

Almeida Maria,

Boman Arne,

Lundstedt Torbjörn

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.559

Subject(s) - chemistry , yield (engineering) , decarboxylation , electrophilic substitution , iodobenzene , medicinal chemistry , electrophile , dimethylformamide , bicarbonate , stereochemistry , organic chemistry , catalysis , materials science , solvent , metallurgy

14 C‐Labelled N ‐(2‐chloro‐3,4‐dimethoxybenzylideneamino)guanidinium acetate has been synthesized as a part of a four‐step procedure which involved decarboxylation of 2‐chloro‐3,4‐dimethoxybenzoic acid by Pb(OAc) 4 to give 2‐chloro‐3,4‐dimethoxy‐1‐iodobenzene, followed by a selective lithiation at the iodine position and electrophilic substitution with N , N ‐dimethylformamide [ α ‐ 14 C] and final reaction with aminoguanidine bicarbonate. The specific activity was 59 mCi/mmol and the overall yield 49%. Copyright © 2002 John Wiley & Sons, Ltd.

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