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Synthesis of N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide and N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐ N ‐[ 14 C]methyl‐benzamide as novel carbon‐14 labelled CCK antagonists
Author(s) -
Matloubi Hojatollah,
Khalaj Ali,
Dowlatabadi Reza,
Shirvani Gholamhossein
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.555
Subject(s) - benzamide , chemistry , methyl iodide , stereochemistry , medicinal chemistry , iodide , organic chemistry
Two benzodiazepine CCK antagonists N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide 2 and N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[ 14 C]methyl‐benzamide 3 were synthesized in high yields through the reaction of N ‐(2,3‐dihydro‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide 1 with [ 14 C] methyl iodide in different situations. Copyright © 2002 John Wiley & Sons, Ltd.