Synthesis of  N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide and  N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐ N ‐[ 14 C]methyl‐benzamide as novel carbon‐14 labelled CCK antagonists | Zendy

Matloubi Hojatollah | Zendy; Khalaj Ali | Zendy; Dowlatabadi Reza | Zendy; Shirvani Gholamhossein | Zendy

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Synthesis of N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide and N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐ N ‐[ 14 C]methyl‐benzamide as novel carbon‐14 labelled CCK antagonists

Author(s) -

Matloubi Hojatollah,

Khalaj Ali,

Dowlatabadi Reza,

Shirvani Gholamhossein

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.555

Subject(s) - benzamide , chemistry , methyl iodide , stereochemistry , medicinal chemistry , iodide , organic chemistry

Two benzodiazepine CCK antagonists N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide 2 and N ‐(2,3‐dihydro‐1‐[ 14 C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[ 14 C]methyl‐benzamide 3 were synthesized in high yields through the reaction of N ‐(2,3‐dihydro‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide 1 with [ 14 C] methyl iodide in different situations. Copyright © 2002 John Wiley & Sons, Ltd.

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