Preparation of N′ 4 ‐[ 11 C]methyl‐ciprofloxacin for positron emission tomography studies | Zendy

Goethals Patrick | Zendy; Volkaert Anneke | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Preparation of N′ 4 ‐[ 11 C]methyl‐ciprofloxacin for positron emission tomography studies

Author(s) -

Goethals Patrick,

Volkaert Anneke

Publication year - 2002

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.545

Subject(s) - chemistry , methyl iodide , positron emission tomography , high performance liquid chromatography , yield (engineering) , ciprofloxacin , nuclear chemistry , radiochemistry , positron , chromatography , nuclear medicine , medicinal chemistry , medicine , materials science , metallurgy , biochemistry , physics , quantum mechanics , electron , antibiotics

The synthesis of N′ 4 ‐[ 11 C]methyl‐ciprofloxacin for pharmacological studies using positron emission tomography is described. The starting material was treated with [ 11 C]methyl iodide at 120°C in DMF for 5 min. After HPLC separation on a C 18 ‐column with water/ethanol as mobile phase, the [ 11 C]methyl labelled compound was produced with a radiochemical yield of at least 25% (end of synthesis from [ 11 C]CO 2 ). Activities from 1.48 to 2.22 GBq (40 to 60 mCi) were obtained 1 h after the irradiation, ready for intravenous injection. The carrier ranged between 0.05 and 0.08 μmol (0.010–0.016 μmol/ml). Copyright © 2002 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research