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Preparation of N′ 4 ‐[ 11 C]methyl‐ciprofloxacin for positron emission tomography studies
Author(s) -
Goethals Patrick,
Volkaert Anneke
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.545
Subject(s) - chemistry , methyl iodide , positron emission tomography , high performance liquid chromatography , yield (engineering) , ciprofloxacin , nuclear chemistry , radiochemistry , positron , chromatography , nuclear medicine , medicinal chemistry , medicine , materials science , metallurgy , biochemistry , physics , quantum mechanics , electron , antibiotics
The synthesis of N′ 4 ‐[ 11 C]methyl‐ciprofloxacin for pharmacological studies using positron emission tomography is described. The starting material was treated with [ 11 C]methyl iodide at 120°C in DMF for 5 min. After HPLC separation on a C 18 ‐column with water/ethanol as mobile phase, the [ 11 C]methyl labelled compound was produced with a radiochemical yield of at least 25% (end of synthesis from [ 11 C]CO 2 ). Activities from 1.48 to 2.22 GBq (40 to 60 mCi) were obtained 1 h after the irradiation, ready for intravenous injection. The carrier ranged between 0.05 and 0.08 μmol (0.010–0.016 μmol/ml). Copyright © 2002 John Wiley & Sons, Ltd.