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Synthesis of 13 C and 15 N multilabeled 5‐aminolevulinic acid
Author(s) -
Iida Katsumi,
Kajiwara Masahiro
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.541
Subject(s) - chemistry , hydrolysis , condensation , phthalic acid , carbon 14 , chloride , phthalic anhydride , medicinal chemistry , glycine , radiochemistry , nuclear chemistry , organic chemistry , catalysis , amino acid , biochemistry , physics , thermodynamics , quantum mechanics
5‐[4‐ 13 C, 15 N]‐ and 5‐[5‐ 13 C, 15 N]Aminolevulinic acid (ALA) were simply synthesized in four steps by the condensation of [1‐ 13 C, 15 N]‐ or [2‐ 13 C, 15 N]glycine, respectively, with phthalic anhydride, followed by conversion to the chloride, coupling reaction with a three‐carbon unit and hydrolysis. Copyright © 2002 John Wiley & Sons, Ltd.