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Synthesis of 13 C‐labelled cinnamonitrile
Author(s) -
Zippi Elizabeth M.,
Kamperman Evan
Publication year - 2002
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.535
Subject(s) - chemistry , acrylonitrile , nitrile , cyanide , radiochemistry , potassium cyanide , styrene , potassium , nuclear chemistry , proton , organic chemistry , copolymer , nuclear physics , polymer , physics
13 C‐labelled cinnamonitrile, a compound that possesses both the aromatic functionality of styrene and the nitrile functionality of acrylonitrile has been synthesized in one step using β ‐bromostyrene and potassium [ 13 C]cyanide. The preparation of a target material using 13 C ‐labelled cinnamonitrile may provide a cost‐effective method for producing nitrogen‐13 via proton irradiation for Positron Emission Tomography. Copyright © 2002 John Wiley & Sons, Ltd.