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Investigations into the regioselective deuteriation of enolates derived from silyl enol ethers and enolacetates
Author(s) -
Coumbarides Gregory S.,
Eames Jason,
Weerasooriya Neluka
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.519
Subject(s) - regioselectivity , chemistry , enol , silylation , lithium (medication) , silyl enol ether , enol ether , silyl ether , ether , similarity (geometry) , ketone , stereochemistry , medicinal chemistry , organic chemistry , catalysis , psychology , image (mathematics) , artificial intelligence , psychiatry , computer science
Results are reported on the regioselective C ‐deuteriation of a series of enolates derived from the addition of MeLi to the related enolacetate and silyl enol ether and discussed in terms of the similarity between these methods; comments are made on the possible role of the additive, lithium tert ‐butoxide. Copyright © 2001 John Wiley & Sons, Ltd.