Premium
Synthesis of 14 C‐labeled E4010
Author(s) -
Watanabe N.,
Tokumura T.,
Nakamura T.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.509
Subject(s) - chemistry , yield (engineering) , radiochemistry , carbon 14 , specific activity , high performance liquid chromatography , pharmacokinetics , chemical synthesis , chromatography , nuclear chemistry , organic chemistry , biochemistry , in vitro , enzyme , pharmacology , medicine , physics , materials science , quantum mechanics , metallurgy
14 C‐Labeled E4010, [4‐(3‐chloro‐4‐methoxybenzyl)amino‐1‐(4‐hydroxy) ‐piperidino]‐6‐[4‐ 14 C]phthalazinecarbonitrile monohydrochloride was synthesized for drug metabolism and pharmacokinetic studies using [1‐chloro‐4‐(3‐chloro‐4‐methoxybenzyl)amino]‐6‐[4‐ 14 C]phthalazinecarbonitrile as the starting material. The radiochemical yield was 33.4%. The specific radioactivity and radiochemical purity, as determined by radio‐HPLC and LSC, were 4.77 MBq/mg and 99.8%, respectively. Copyright © 2001 John Wiley & Sons, Ltd.