Improved specific Synthesis of [1′‐ 15 N]‐ and [3′‐ 15 N] L ‐histidine | Zendy

SoedeHuijbregts C. | Zendy; van Laren M. | Zendy; Hulsbergen F. B. | Zendy; Raap J. | Zendy; Lugtenburg J. | Zendy

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Improved specific Synthesis of [1′‐ 15 N]‐ and [3′‐ 15 N] L ‐histidine

Author(s) -

SoedeHuijbregts C.,

van Laren M.,

Hulsbergen F. B.,

Raap J.,

Lugtenburg J.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.507

Subject(s) - chemistry , histidine , imidazole , labelling , yield (engineering) , stereochemistry , organic chemistry , biochemistry , enzyme , materials science , metallurgy

Specifically, 15 N‐enriched L ‐histidines have been prepared. The labelling methodology involves introduction of labels in its precursor 1‐benzyl‐5‐hydroxy methyl imidazole, which is converted into L ‐histidine via the Schöllkopf method. The procedure allows the preparation of the intermediates and finally histidine with high 15 N enrichment (99%) at each position, in 29% overall yield starting with 15 NH 4 Cl and 56% with KSC 15 N, respectively. Copyright © 2001 John Wiley & Sons, Ltd.

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