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The improved biological properties in mice of 99m Tc–TBI for myocardial perfusion imaging
Author(s) -
Zhang X. Zh.,
Wang X. B.,
Tang Z. G.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.493
Subject(s) - biodistribution , myocardial perfusion imaging , perfusion , chemistry , imaging agent , lung , perfusion scanning , technetium , nuclear medicine , medicine , in vivo , nuclear chemistry , in vitro , biochemistry , microbiology and biotechnology , biology
The aim of this study was to improve the biological properties of 99m Tc–TBI complex for myocardial perfusion imaging. The effect of Tween‐80 on the biodistribution in mice of 99m Tc–TBI was reported. The experimental results show that liver and blood uptakes of Tween‐80 added (TA) complex are significantly lower than those of corresponding non‐Tween‐80 added (NTA) complex. Also, the clearance rate from blood of TA complex is faster than that of NTA complex. At 60 min post‐injection time, the ratios of heart‐to‐liver, heart‐to‐lung and heart‐to‐blood were 1.29, 137.75 and 4.73, respectively, for the TA complex; however, the corresponding ratios were 0.57, 13.07 and 2.65, respectively, for NTA complex. The biodistribution in mice of the Tween‐80 added 99m Tc–TBI ( 99m Tc–TBI(T)) is comparable with the widely used myocardial perfusion imaging agent 99m Tc–MIBI in some aspects; especially, the heart‐to‐liver ratios of 99m Tc–TBI(T) at various post‐injection times are better than those of 99m Tc–MIBI. The biological properties of 99m Tc–TBI complex for myocardial imaging were improved significantly by using Tween‐80 as an auxiliary agent. It is worthy of further studies. Copyright © 2001 John Wiley & Sons, Ltd.