Premium
Preparation of carbon‐14 labelled ampropylfos (1‐[ 14 C]‐ α ‐aminopropanephosphonic acid)
Author(s) -
Hudson Harry R.,
Ismail Fatima
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.486
Subject(s) - chemistry , boron trifluoride , toluene , carbamate , hydrolysis , carbon 14 , organic chemistry , medicinal chemistry , specific activity , nuclear chemistry , catalysis , enzyme , physics , quantum mechanics
1‐[ 14 C]‐ α ‐Aminopropanephosphonic acid, with a specific activity of 1.736 µCi mg −1 , has been prepared from 1‐[ 14 C]‐propanal, triphenyl phosphite, and benzyl carbamate by interaction in toluene in the presence of boron trifluoride‐etherate, followed by hydrolysis. The product was shown by single crystal X‐ray diffraction to be structurally identical to an unlabelled specimen. Copyright © 2001 John Wiley & Sons, Ltd.