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Synthesis of the [ 3 H] labelled potent and selective peripheral benzodiazepine receptor ligand CB 34
Author(s) -
Latrofa A.,
Trapani G.,
Franco M.,
Harris M.J.,
Serra M.,
Biggio G.,
Liso G.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.481
Subject(s) - chemistry , ligand (biochemistry) , benzodiazepine , catalysis , receptor , stereochemistry , gabaa receptor , combinatorial chemistry , biochemistry
The synthesis of the [ 3 H] labelled peripheral benzodiazepine receptor (PBR) ligand CB 34, useful for binding assay, tissue distribution studies, and elucidation of the physiological role of PBR, is described. Catalytic reduction with 3 H 2 gas and 10% Pd/C catalyst of the key intermediate 2 afforded the product at a specific activity of 111 Ci/mmol. Copyright © 2001 John Wiley & Sons, Ltd.
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