Synthesis of ring‐ 14 C‐labelled 4(3′‐, 6′‐dimethyl‐3′‐heptyl)‐phenol | Zendy

Lalah J. O. | Zendy; Lenoir D. | Zendy; Henkelmann B. | Zendy; Hertkorn N. | Zendy; Günther K. | Zendy; Schramm K.W. | Zendy; Kettrup A. | Zendy

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Synthesis of ring‐ 14 C‐labelled 4(3′‐, 6′‐dimethyl‐3′‐heptyl)‐phenol

Author(s) -

Lalah J. O.,

Lenoir D.,

Henkelmann B.,

Hertkorn N.,

Günther K.,

Schramm K.W.,

Kettrup A.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.474

Subject(s) - chemistry , anisole , phenol , alkylation , bromide , ring (chemistry) , yield (engineering) , ether , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy

Ring‐ 14 C‐labelled 4(3′‐, 6′‐, dimethyl‐3′‐,heptyl)‐phenol (NP), an isomer of paranonyl phenol was synthesized for use in aquatic toxicity and metabolism studies. A very efficient method involving alkylation of ring‐ 14 C‐labelled anisole and tertiary alkyl bromide (3‐bromo‐3,6‐dimethyl heptane) with AlCl 3 followed by cleavage of the resultant ether with BBr 3 was used giving a 24% yield ring labelled 14 C‐NP (specific activity: 16.205 MBq/mg and purity >95% by HPLC) after TLC separation. Copyright © 2001 John Wiley & Sons, Ltd.

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