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A convenient synthesis of [2,6‐ 14 C]‐2‐chloroisonicotinic acid
Author(s) -
Kelly Terence P.,
Rodgers Thomas R.,
Wright Christopher
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.473
Subject(s) - chemistry , potassium hydroxide , carbonation , hydrazine (antidepressant) , potassium , hydroxide , nuclear chemistry , medicinal chemistry , organic chemistry , chromatography
[2,6‐ 14 C]‐2‐chloroisonicotinic acid ( 1 ) was prepared by kinetically controlled lithiation and carbonation of [2,6‐ 14 C]‐2,6‐dichloropyridine, followed by reduction using hydrazine and potassium hydroxide. Copyright © 2001 John Wiley & Sons, Ltd.