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Synthesis of 10,11,14,15‐ 13 C 4 ‐and 14,15‐ 13 C 2 ‐retinyl acetate
Author(s) -
Tanumihardjo Sherry A.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.464
Subject(s) - chemistry , isotope dilution , retinyl acetate , isotope , mass spectrometry , chromatography , specific activity , radiochemistry , organic chemistry , biochemistry , retinol , vitamin , enzyme , physics , quantum mechanics
The synthesis of 10,11,14,15‐ 13 C 4 ‐ and 14,15‐ 13 C 2 ‐retinyl acetate is described. The procedure uses a modified Wittig‐Horner synthesis. By using the 13 C isotope, sensitive gas chromatography‐combustion‐isotope ratio mass spectrometry can be used for analysis in application to human isotope dilution studies. Copyright © 2001 John Wiley & Sons, Ltd.