Synthesis of tritium labeled [3R‐ 3 H]‐, and [3S‐ 3 H]‐L‐phenylalanine | Zendy

Jemielity J. | Zendy; Kanski R. | Zendy; Kanska M. | Zendy

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Synthesis of tritium labeled [3R‐ 3 H]‐, and [3S‐ 3 H]‐L‐phenylalanine

Author(s) -

Jemielity J.,

Kanski R.,

Kanska M.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.461

Subject(s) - chemistry , isotopomers , phenylalanine , tritiated water , benzaldehyde , ammonia , tritium , cinnamic acid , phenylalanine ammonia lyase , radiochemistry , enzyme , organic chemistry , amino acid , catalysis , biochemistry , molecule , physics , nuclear physics

The synthesis of two selectively labeled isotopomers of L‐phenylalanine, (Phe), using chemical and enzymatic methods is reported. The [3R‐ 3 H]‐L‐Phe isotopomer has been obtained from [3‐ 3 H]cinnamic acid prepared from benzaldehyde and malonic acid using tritiated water as a source of radioactive label, and by addition of ammonia in the presence of enzyme PAL. The [3S‐ 3 H]‐L‐Phe isotopomer has been synthesized by addition of ammonia to cinnamic acid in a buffered medium containing PAL and tritiated water. Copyright © 2001 John Wiley & Sons, Ltd.

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