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N,N′,N″,N‴‐tetraalkylcyclam derivatives: synthesis, 99m Tc‐labelling and biological properties
Author(s) -
Jeong Jae Min,
Hong Sung Hyun,
Kim Young Joo,
Lee Dong Soo,
Chung JuneKey,
Cho JungHyuck,
Lee Myung Chul
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.448
Subject(s) - chemistry , lipophilicity , labelling , alkyl , stereochemistry , medicinal chemistry , organic chemistry , biochemistry
We synthesized N , N ′, N ″, N ‴‐tetraalkylcyclam derivatives in which alkyl groups were ethyl, propyl, butyl, methoxyethyl, and ethoxyethyl. We attempted to label the compounds with 99m Tc. The cyclams with methyl, ethyl, and propyl could be labelled. The labelled N , N ′, N ″, N ‴‐tetraalkylcyclam derivatives showed +1 charge. They excreted rapidly through the kidney in mice. The liver‐uptake increased slightly as the lipophilicity increased. However, the myocardial uptake was low unlikely with the +1 charged myocardial imaging agents. Copyright © 2001 John Wiley & Sons, Ltd.