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Organoiridium catalysed hydrogen isotope exchange of benzamide derivatives
Author(s) -
Valsborg Jacob S.,
Sørensen Lone,
Foged Christian
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.446
Subject(s) - benzamide , chemistry , acetanilide , tritium , hydrogen isotope , amide , catalysis , hydrogen , medicinal chemistry , radiochemistry , nuclear chemistry , organic chemistry , physics , nuclear physics
Hydrogen‐tritium exchange in a series of benzamide derivatives and acetanilide has been investigated using [Ir(cod)(Cy 3 P)(Py)]PF 6 as catalyst. Specific activities of 6–43 Ci/mmol were obtained. Tritium NMR spectroscopy showed that exchange occurred ortho to the amide group. Copyright © 2001 John Wiley & Sons, Ltd.