Preparation of [2a,8a,10a,14a‐ 3 H]geldanamycin by biosynthesis | Zendy

Taylor George F. | Zendy; Foarde Karin K. | Zendy; Webber Tricia D. | Zendy; Kepler John A. | Zendy

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Preparation of [2a,8a,10a,14a‐ 3 H]geldanamycin by biosynthesis

Author(s) -

Taylor George F.,

Foarde Karin K.,

Webber Tricia D.,

Kepler John A.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.443

Subject(s) - geldanamycin , chemistry , streptomyces hygroscopicus , tritium , specific activity , biosynthesis , catalysis , stereochemistry , chemical synthesis , fermentation , biochemistry , hsp90 , enzyme , in vitro , streptomyces , bacteria , genetics , heat shock protein , physics , biology , nuclear physics , gene

[3‐ 3 H]Propionic acid ( 1 ) was prepared by catalytic hydrogenation of 3‐bromo‐propionic acid with tritium gas. Fermentations of S. hygroscopicus were treated with 1 to produce [2a,8a,10a,14a‐ 3 H]geldanamycin ( 2 ) with a specific activity of 76.2 mCi/mmol. The effect of the amount of 1 used and the dosing pattern on the specific activity of 2 was investigated. Copyright © 2001 John Wiley & Sons, Ltd.

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